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Massive perivillous fibrin deposition (MPFD, or MFD) refers to excessive deposition of fibrous tissue around the chorionic villi of the placenta. It causes reduced growth of the foetus, and leads to miscarriage in nearly 1 in 3 pregnancies affected. There are typically no symptoms, and it is rarely detected before birth.
Breus mole is reported to be found in the placentas of macerated stillborn foetuses, indicating that massive subchorionic hematoma could have been the cause of their demise. [2] A massive Breus' mole can cause disturbances in blood flow in the spiral arteries and might result in intrauterine growth restriction of the foetus.
Ultrasound showing a subchorionic hemorrhage [1] Chorionic hematoma is the pooling of blood ( hematoma ) between the chorion , a membrane surrounding the embryo , and the uterine wall . [ 2 ] It occurs in about 3.1% of all pregnancies , [ 2 ] it is the most common sonographic abnormality and the most common cause of first trimester bleeding .
This thick ring of membranes is composed of a double fold of amnion and chorion with degenerated decidua vera and fibrin in between. Blood vessels, supplying nutrients and carrying waste products to and from the developing fetus, radiate from the umbilical cord insertion to as far as the ring of membranes, and then disappears from view. [4]
Histopathology of acute subchorionic intervillositis, with neutrophils in Langhan’s layer of fibrinoid (by the fetal surface, at the base of a chorionic villus, seen at top right). Placentitis is an inflammation of the placenta. The main forms of placentitis are: Villitis, inflammation of chorionic villi.
Fibrinogen disorders are a set of hereditary or acquired abnormalities in the quantity and/or quality of circulating fibrinogens.The disorders may lead to pathological bleeding and/or blood clotting or the deposition of fibrinogen in the liver, kidneys, or other organs and tissues.
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Villitis of unknown etiology (VUE), also known as chronic villitis, is a placental injury.VUE is an inflammatory condition involving the chorionic villi (placental villi). ). VUE is a recurrent condition and can be associated with intrauterine growth restriction (I