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An autoimmune response to Type II collagen, which is found in cartilage and the sclera of the eye, may play a role in the pathophysiology of RP. [5] A genetic connection to HLA-DR4 (DRB1*04 subtype alleles) may also exist. [5] About 30% of cases of RP are linked to additional illnesses, such as autoimmune disorders. [5]
The autoimmune reaction most commonly affects the oral mucosa in the mouth, causing lesions in the gums (gingiva), known as desquamative gingivitis.More severe cases can also affect areas of mucous membrane elsewhere in the body, such as the sinuses, genitals, anus, and cornea. [5]
Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen vascular diseases can be (but are not necessarily) associated with collagen and blood vessel abnormalities that are autoimmune in nature. Some connective tissue diseases have strong or weak genetic inheritance risks. Others ...
dry eyes, dry mouth, hair loss, joint inflammation, joint pain, mouth ulcers, positive ANA test, raynaud's phenomenon, sun-sensitive rash... Undifferentiated connective tissue disease ( UCTD ) (also known as latent lupus or incomplete lupus [ 1 ] ) is a disease in which the connective tissues are targeted by the immune system.
The mouth is the only place in the body which provides the sensation of taste. Due to these unique physiological features, the oral mucosa must fulfil a number of distinct functions. Protection: One of the main functions of the oral mucosa is to physically protect the underlying tissues from the mechanical forces, microbes and toxins in the ...
Throat or mouth disorders, including post-nasal drip or enlarged tonsils, can affect the initiation of swallowing. Eosinophilic esophagitis, an immune system reaction to certain foods, allergens ...
Autoimmune diseases predominantly begin in adulthood, although they can start at any age. [1] The initial recognition of autoimmune diseases dates back to the early 1900s, and since then, advancements in understanding and management of these conditions have been substantial, though much more is needed to fully unravel their complex etiology and ...
The idea behind the "mixed" disease is that this specific autoantibody is also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. MCTD was characterized as an individual disease in 1972 by Sharp et al., [3] [4] and the term was introduced by Leroy [5] in 1980. [6]