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Cannabidiol (CBD) is a ... Side effects of CBD are dose related. [50] ... In February 2020, the UK FSA advised vulnerable people, such as pregnant women ...
7-Hydroxycannabidiol (7-OH-CBD) is an active metabolite of cannabidiol, generated in the body from cannabidiol by the action of the enzyme CYP2C19. [1] While methods have been developed for its synthetic production, [2] and measurement of levels in the body following consumption of cannabidiol, [3] its pharmacology has been relatively little studied, though it has been found to possess similar ...
In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index , [ 21 ] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation.
[3] [4] Cannabidiol (CBD) is another major constituent of some cannabis plants. [5] Conversion of CBD to THC can occur when CBD is heated to temperatures between 250–300 °C (480 to 570°F), potentially leading to its partial transformation into THC. [6] At least 113 distinct cannabinoids have been isolated from cannabis. [7]
Cannabitriol (CBT) is a phytocannabinoid first isolated in 1966, [1] [2] [3] an oxidation product of tetrahydrocannabinol (THC) which has been identified both as a trace component of cannabis and as a metabolite in cannabis users. [4]
Cannabidiol has little affinity for CB 1 and CB 2 receptors but acts as an indirect antagonist of cannabinoid agonists. [25] It was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in the caudate nucleus and putamen. [26] Cannabidiol has also been shown to act as a 5-HT 1A receptor agonist. [27]
Vin Diesel announced that “Fast X: Part 2” will finish shooting in Los Angeles, the city that provided the setting for the first film in the long-running franchise, as a way to bolster a local ...
It is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors and is mainly active as an agonist of the TRPV2 cation channel, through which it produces antiinflammatory effects, [ 1 ] but can also promote tumorigenesis at high concentrations.