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Sodium glycerophosphate, sold under the brand name Glycophos, is a medication used to supplement phosphate. [3] [4] It is administered via intravenous infusion. [3] [4] Sodium glycerophosphate is an organic phosphate salt. [3] [4] It was approved for medical use in Australia in November 2019. [5] [3] [6]
It is diagnosed based on a blood phosphate concentration of less than 0.81 mmol/L (2.5 mg/dL). [1] When levels are below 0.32 mmol/L (1.0 mg/dL) it is deemed to be severe. [2] Treatment depends on the underlying cause. [1] Phosphate may be given by mouth or by injection into a vein. [1]
The enzyme 3′(2′),5′-bisphosphate nucleotidase (EC 3.1.3.7) catalyzes the reaction adenosine 3′,5′-bisphosphate + H 2 O ⇌ {\displaystyle \rightleftharpoons } AMP + phosphate This enzyme belongs to the family of hydrolases , specifically those acting on phosphoric monoester bonds.
Thus, the two substrates of this enzyme are guanosine 5'-triphosphate,3'-diphosphate and H 2 O, whereas its two products are guanosine 5'-diphosphate,3'-diphosphate and phosphate. This enzyme belongs to the family of hydrolases , specifically those acting on acid anhydrides in phosphorus-containing anhydrides.
The OCP Group (OCP S.A.) (formerly Office Chérifien des Phosphates) is a Moroccan state-owned phosphate rock miner, phosphoric acid manufacturer and fertilizer producer. [2] [3] Founded in 1920, the company has grown to become the world's largest producer of phosphate and phosphate-based products and it is one of the largest phosphate, fertilizer, chemicals, and mineral industrial companies ...
The phosphate serves as a link to another alcohol-usually ethanolamine, choline, serine, or a carbohydrate. The identity of the alcohol determines the subcategory of the phosphatidate. There is a negative charge on the phosphate and, in the case of choline or serine, a positive quaternary ammonium ion. (Serine also has a negative carboxylate ...
TCEP is available from various chemical suppliers as the hydrochloride salt. When dissolved in water, TCEP-HCl is acidic. A reported preparation is a 0.5 M TCEP-HCl aqueous stock solution that is pH adjusted to near-neutral pH and stored frozen at -20˚C. [12] TCEP is reportedly less stable in phosphate buffers. [12]
Phosphate nephropathy or nephrocalcinosis [1] is an adverse renal condition that arises with a formation of phosphate crystals within the kidney's tubules. This renal insufficiency is associated with the use of oral sodium phosphate (OSP) such as C.B. Fleet's Phospho soda and Salix's Visocol, for bowel cleansing prior to a colonoscopy.