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For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.
There are various competing calculation methods for the drug accumulation ratio, yielding somewhat different results. A commonly used formula defines R ac as the ratio of the area under the curve (AUC) during a single dosing interval under steady state conditions to the AUC during a dosing interval after one single dose: [1]
Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. [4] AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [5]
Assets under management is a popular metric used within the traditional investment industry as well as for {decentralized finance} , [3] such as cryptocurrency, to measure the size and success of an investment management entity. [4] AUM represents the market value of all of the securities that a financial entity owns and manages, or simply ...
Small caps: Small-capitalization stocks, or small caps, are smaller companies, with a total value of their outstanding stock up to about $2 billion or so. Many great companies began as small caps ...
The exact definition of a penny stock varies, but typically they include stocks trading for less than $5 per share all the way down to even fractions of a penny.