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For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. [3] AUC becomes useful for knowing the average concentration over a time interval, AUC/t.
The Dow jumped 700 points and the Nasdaq gained more than 2% as investors cheered encouraging inflation data and a strong start to earnings season.
Phi measures how better (or worse) is a classification, with respect to the random classification, which is characterized by Phi = 0. According to the reference values suggested by Cohen, [8] one can take Phi = 0.35 as a minimum acceptable level of Phi for a classification. In the ROC space, Phi equal to a non null constant corresponds to the ...
Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. [4] AUC is used because AUC is proportional to the dose that has entered the systemic circulation. [5]
Here's what else happened today: Disney said it will appoint Bob Iger's successor as CEO by early 2026. Goldman Sachs said investors should prepare for a decade of muted returns in the stock market.
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