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The verocytotoxin (shiga-like toxin) can directly damage renal and endothelial cells. Thrombocytopenia occurs as platelets are consumed by clotting. Hemolytic anemia results from intravascular fibrin deposition, increased fragility of red blood cells, and fragmentation.
Microbiologists use many terms to describe Shiga toxin and differentiate more than one unique form. Many of these terms are used interchangeably. Shiga toxin type 1 and type 2 (Stx-1 and 2) are the Shiga toxins produced by some E. coli strains. Stx-1 is identical to Stx of Shigella spp. or differs by only one amino acid. [6]
The strain has a number of virulence genes typical of enteroaggregative E. coli, including attA, aggR, aap, aggA, and aggC, in addition to the Shiga toxin variant 2. [26] All bacteria isolated from patients in this outbreak were resistant to beta-lactam antibiotics, third-generation cephalosporins , and partially resistant to nalidixic acid ...
Some strains of E. coli, for example O157:H7, can produce Shiga toxin. The Shiga toxin causes inflammatory responses in target cells of the gut, leaving behind lesions which result in the bloody diarrhea that is a symptom of a Shiga toxin-producing E. coli (STEC) infection.
E. coli Shiga-like toxin II B subunit: Clinical data; ATC code: ... The drug is designed to bind to a toxin of this bacterium, ... [2] References This page was last ...
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Shiga-toxin directly activates the alternative complement pathway and also interferes with complement regulation by binding to complement factor H, an inhibitor of the complement cascade. Shiga-toxin causes complement-mediated platelet, leukocyte, and endothelial cell activation, resulting in systemic hemolysis, inflammation and thrombosis.
E. coli shiga toxin type-2: Setrusumab [26] mab: human: sclerostin (SOST) Sevirumab: human: cytomegalovirus: cytomegalovirus infection Sibrotuzumab: mab: humanized: FAP (gene) (FAP) cancer SGN-CD19A: mab: humanized: CD19: acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma SHP647: human: mucosal addressin cell adhesion molecule: Crohn ...