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Because of misinformation suggesting that COVID-19 might alter DNA, some academics insisted that mRNA vaccines were not a "gene therapy" to prevent the spread of this misinformation, but others said that mRNA vaccines were a gene therapy because they introduce genetic material into cells.
The COVID-19 mRNA vaccines from Moderna and Pfizer–BioNTech had short-term efficacy rates of over 90 percent against the original SARS-CoV-2 virus. Prior to mRNA, drug trials on pathogens other than COVID-19 were not effective and had to be abandoned in the early phases of trials. The reason for the efficacy of the new mRNA vaccines is not clear.
Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis , transmissibility , or host range , i.e., the types of hosts that a microorganism can infect.
Gene therapy may be classified into two types by the type of cell it affects: somatic cell and germline gene therapy. In somatic cell gene therapy (SCGT), the therapeutic genes are transferred into any cell other than a gamete, germ cell, gametocyte, or undifferentiated stem cell.
Genetic vaccines are most commonly administered by injection (intramuscular or subcutaneous) or infusion, and less commonly and for DNA, by gene gun or electroporation. While viral vectors have their own mechanisms to be taken up into cells, DNA and RNA must be introduced into cells via a method of transfection .
GX_P2V is a COVID-19 mutant strain that is fatal to humanized mice with the hACE2 gene. [ 1 ] The Chinese government has been performing tests on GX_P2V and has published a new study. [ 2 ] “ This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2 related ...
In diseases that are secondary to a genetic mutation that causes the lack of a gene, the gene is added back in. [24] [25] [26] In diseases that are due to the overexpression of a gene, viral genetic engineering may be introduced to turn off the gene. [24] [25] [26] Viral gene therapy may be done in vivo or ex vivo.
With the discovery of various types of immune-related disorders, there is a need for diversification in prevention and treatment. Developments in the field of gene therapy are being studied to be included in the scope of this treatment, but of course more research is needed to increase the positive results and minimize the negative effects of gene therapy applications. [27]