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Elevated homocysteine is a known risk factor for cardiovascular disease as well as thrombosis. [7] It has also been shown to be associated with microalbuminuria which is a strong indicator of the risk of future cardiovascular disease and renal dysfunction. [8]
High levels of homocysteine in the blood (hyperhomocysteinemia) is regarded as a marker of cardiovascular disease, likely working through atherogenesis, which can result in ischemic injury. Therefore, hyperhomocysteinemia is a possible risk factor for coronary artery disease .
Elevated homocysteine is an independent risk factor for cardiovascular disease and inversely correlated to consumed vitamin B12/B6 and folate levels. [37] Homocysteine methylation to methionine is catalyzed by MTR, resulting in appropriate intracellular levels of methionine and tetrahydrofolate, alongside non-toxic homocysteine levels.
There is also an elevated risk of neural tube defects among children of individuals with the C677T polymorphism (odds ratio 1.38). [6] Common MTHFR deficiencies were once thought to be associated with cardiovascular risk, but meta-analyses indicate that correlation this was an artifact of publication bias. [clarification needed] [7] [8]
Frailty is associated with an increased vulnerability to fractures, falls from heights, reduced cognitive function and more frequent hospitalisation. [99] The worldwide prevalence of frailty within the geriatric population is 13.9%, [100] therefore there is an urgent need to eliminate any risk factors associated with frailty. Poor vitamin B ...
Research shows that diets that contain ultra-processed foods (like potato chips, candy, fast food, hot dogs, etc.) may be associated with more of a risk of immune dysregulation-linked diseases ...
Other risk factors that are being studied include levels of various inflammatory mediators such as C-reactive protein, fibrinogen, homocysteine, and lipoprotein A. [49] Individuals with increased levels of homocysteine in their blood have a 2-fold risk of developing peripheral artery disease. [36]
Uwazurike explains that a waist-to-hip ratio of higher than 0.9 for men and 0.85 for women suggests a potentially elevated chance of developing health problems. ... Estimated visceral adiposity is ...