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The Suzuki reaction or Suzuki coupling is an organic reaction that uses a palladium complex catalyst to cross-couple a boronic acid to an organohalide. [1] [2] [3] It was first published in 1979 by Akira Suzuki, and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their contribution to the discovery and development of noble metal catalysis in organic ...
Norio Miyaura (宮浦憲夫, Miyaura Norio) was a Japanese organic chemist. He was a professor of graduate chemical engineering at Hokkaido University. [1] His major accomplishments surrounded his work in cross-coupling reactions / conjugate addition reactions of organoboronic acids (for C-C bond-forming reactions) and addition / coupling reactions of diborons and boranes (to synthesize ...
Cross-coupling reactions are important for the production of pharmaceuticals, [4] examples being montelukast, eletriptan, naproxen, varenicline, and resveratrol. [21] with Suzuki coupling being most widely used. [22] Some polymers and monomers are also prepared in this way. [23]
The Miyaura borylation has shown to work for: Alkyl halides, [ 2 ] aryl halides, [ 1 ] [ 3 ] [ 4 ] aryl halides using tetrahydroxydiboron , [ 5 ] aryl halides using bis-boronic acid, [ 6 ] aryl triflates , [ 7 ] aryl mesylates , [ 8 ] vinyl halides, [ 9 ] vinyl halides of α,β-unsaturated carbonyl compounds, [ 10 ] and vinyl triflates.
Typically the electrophilic coupling partner (R-X) is an aryl halide, but triflates are also used. Nucleophilic coupling (R'-Y) partners are more diverse. In the Suzuki reaction, boronic esters and boronic acids serve as nucleophilic coupling partners. [1] Expanding the scope of coupling partners is a focus methods development in organic ...
Dixon Valve & Coupling Company, LLC [1] is a manufacturer and supplier of hose fittings and accessories. The company, often referred to as just Dixon, offers products for fire protection, food processing, dairy processing, beverage and brewery operations, industrial manufacturing, mining, construction, chemical processing, petroleum processing and refining, oilfields, mobile tankers and ...
Among the cross-coupling reactions it follows in the number of publications right after Suzuki and Heck reaction [8] and a search for the term "Sonogashira" in SciFinder provides over 1500 references for journal publications between 2007 and 2010. [7]
The most common type of coupling reaction is the cross coupling reaction. [1] [2] [3] Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki were awarded the 2010 Nobel Prize in Chemistry for developing palladium-catalyzed cross coupling reactions. [4] [5] Broadly speaking, two types of coupling reactions are recognized: