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Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
The dopamine receptors are members of the G protein-coupled receptors superfamily with seven transmembrane domains. Dopamine receptors have five subtypes, D 1 through D 5, the subtypes can be divided into two subclasses due to their mechanism of action on adenylate cyclase enzyme, D 1-like receptors (D 1 and D 5) and D 2-like receptors (D 2, D ...
Download as PDF; Printable version; In other projects ... These agents stimulate dopamine receptors. In doing so, they alleviate the ... Dopamine agonist; List of ...
Amphetamine, an NDRA and one of the most well-known DRAs. 4-Methylaminorex (4-MAR), the cis- isomer being one of the most dopamine-selective NDRAs known.. A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.
Dopaminergic brain pathways facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT 2), and dopamine receptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopamine receptors in them may also be ...
Levodopa (L-DOPA), a prodrug of dopamine which is used to treat Parkinson's disease and certain other conditions. A neurotransmitter prodrug, or neurotransmitter precursor, is a drug that acts as a prodrug of a neurotransmitter. A variety of neurotransmitter prodrugs have been developed and used in medicine.
Some drugs do not appear to increase motivation and can actually have anti-motivational effects. [4] [13] [19] Examples of these drugs include selective serotonin reuptake inhibitors (SSRIs), [19] [20] [21] selective norepinephrine reuptake inhibitors (NRIs), [19] and antipsychotics (which are dopamine receptor antagonists or partial agonists).
Fenfluramine is an indirect agonist of serotonin receptors. [2] Fenfluramine binds to the serotonin transporter, blocking serotonin reuptake. However, fenfluramine also acts to induce non-exocytotic serotonin release; in a mechanism similar to that of methamphetamine in dopamine neurons, fenfluramine binds to VMAT2, disrupting the compartmentalization of serotonin into vesicles and increasing ...