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Mavrilimumab is a human monoclonal antibody [1] that inhibits human granulocyte macrophage colony-stimulating factor receptor (GM-CSF-R). [2]Mavrilimumab was discovered as CAM-3001 by Cambridge Antibody Technology and is being developed by MedImmune, Inc. [1] as an investigational drug for the treatment of rheumatoid arthritis
It has US Food and Drug Administration (FDA) approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Tumor necrosis factor alpha (TNFα) is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an ...
[15] withdrawn from general use in UK but permitted in terminal patients Dexfenfluramine: 1997 European Union, UK, US Cardiotoxic [3] Propoxyphene (Darvocet/Darvon) 2010 Worldwide Increased risk of heart attacks and stroke. [16] Diacetoxydiphenolisatin: 1971 Australia Hepatotoxicity. [3] Diethylstilbestrol: 1970s US Carcinogen Difemerine: 1986 ...
According to the Arthritis Foundation, glucosamine is one of the most popular supplements for managing arthritic joint pain. Glucosamine is a naturally occurring compound in the body that builds ...
EMA401 is a drug under development for the treatment of peripheral neuropathic pain.Trials were discontinued in 2015, with new trials scheduled to begin March, 2018. [1] It was initially established as a potential drug option for patients suffering pain caused by postherpetic neuralgia. [2]
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.