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Digestion experiments carried out on him by William Beaumont Alexis Bidagan dit St-Martin (April 8, 1802 [ a ] – June 24, 1880) was a Canadian voyageur who is known for his part in experiments on digestion in humans, conducted on him by the American Army physician William Beaumont between 1822 and 1833.
One of the most significant contributions of the experiment was its role in establishing the concept of the gut-brain axis. It was one of the first studies to provide evidence for what would later be recognized as a complex communication system between the digestive system and the central nervous system in regulating hunger. [13]
From Beaumont's Experiments and Observations on the Gastric Juice and the Physiology of Digestion, 1838 (p.27) On June 6, 1822, an employee of the American Fur Company on Mackinac Island named Alexis St. Martin was accidentally shot in the stomach at close range by the discharge of a shotgun loaded with buckshot that injured his ribs and his stomach.
This experiment works because it shows how salivary amylase – a type of enzyme that exists in our saliva – breaks down the starch in the bread into a sweet-tasting sugar.
These experiments included surgically extracting portions of the digestive system from nonhuman animals, severing nerve bundles to determine the effects, and implanting fistulas between digestive organs and an external pouch to examine the organ's contents. This research served as a base for broad research on the digestive system. Further work ...
Micrococcal nuclease (MNase) was first discovered in S. aureus in 1956, [10] protein crystallized in 1966, [11] and characterized in 1967. [12] MNase digestion of chromatin was key to early studies of chromatin structure; being used to determine that each nucleosomal unit of chromatin was composed of approximately 200bp of DNA. [13]