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Mitochondrial uncoupling protein 3 (UCP3) is a members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and transfer of protons from the outer to the inner mitochondrial membrane, reducing the mitochondrial membrane potential in mammalian cells.
Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter.An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.
One is the cytoplasmic state, inhibited by carboxyatractyloside, in which the substrate binding site is accessible to the intermembrane space, which is confluent with the cytosol, i.e. the bovine mitochondrial ADP/ATP carrier 22] [23] the yeast ADP/ATP carrier Aac2p 24] the yeast ADP/ATP carrier Aac3p 24] Another is the matrix state, inhibited ...
Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species. [8] Chromosomal order is 5'-UCP3-UCP2-3'. [9] Mitochondrial Uncoupling Protein 2
An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain.
Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) [5] is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis , and makes a quantitatively important contribution to countering heat loss in babies which would ...
Names of individual SLC members have the following format: [4] where: SLC is the root name (SoLute Carrier)n = an integer representing a family (e.g., 1-52) X = a single letter (A, B, C, ...) denoting a subfamily
Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. [ 1 ] [ 2 ] There is debate as to whether or not this channel is expressed in the cell surface membrane.