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Regeneration in humans is the regrowth of lost tissues or organs in response to injury. This is in contrast to wound healing , or partial regeneration, which involves closing up the injury site with some gradation of scar tissue.
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Hox genes play a massive role in some amphibians and reptiles in their ability to regenerate lost limbs, especially HoxA and HoxD genes. [1]If the processes involved in forming new tissue can be reverse-engineered into humans, it may be possible to heal injuries of the spinal cord or brain, repair damaged organs and reduce scarring and fibrosis after surgery.
The apical ectodermal ridge in embryonic development is very similar to the apical ectodermal cap in limb regeneration. The progress zone can be seen near to the zone of polarizing activity, which instructs cells on how to orient the limb. [8] In vertebrates, epimorphosis relies on blastema formation to proliferate cells into the new tissue.
Targeted reinnervation has an efferent and an afferent component. Targeted muscle reinnervation is a method by which a spare muscle (the target muscle) of an amputated patient is denervated (its original nerves cut and/or de-activated), then reinnervated with residual nerves of the amputated limb. [1]
The limb bud is a structure formed early in vertebrate limb development. As a result of interactions between the ectoderm and underlying mesoderm, formation occurs roughly around the fourth week of development. [1] In the development of the human embryo the upper limb bud appears in the third week and the lower limb bud appears four days later. [2]
Human Playground is a Netflix original docuseries created by Hannelore Vandenbussche [1] and narrated by Idris Elba. [2] It explores several different unique and extreme sports "played" by different cultures around the world. [3] It was released on September 30, 2022. [4]
NBA 2K Playgrounds 2 is a sports video game developed by Saber Interactive and published by 2K, and is a spin-off title of the NBA 2K series and a part of the Playground Sports series. The game was released for Windows, Nintendo Switch, PlayStation 4, Xbox One on October 16, 2018. It is the sequel to the 2017 video game NBA Playgrounds.