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Small-molecule anti-genomic therapeutics, or SMAT, refers to a biodefense technology that targets DNA signatures found in many biological warfare agents. SMATs are new, broad-spectrum drugs that unify antibacterial, antiviral and anti-malarial activities into a single therapeutic that offers substantial cost benefits and logistic advantages for ...
Small molecule drug conjugates or SMDCs are built with three modules: a targeting ligand, a linker and a drug payload [citation needed].The targeting ligands consist of low molecular weight, high-affinity ligands that are precisely linked to potent drugs.
Phage-displayed antibodies can be isolated from large antibody libraries by mimicking molecular evolution: through rounds of selection (on an immobilized protein target), amplification and translation. [2] In DELs the linkage of a small molecule to an identifier DNA code allows the facile identification of binding molecules.
At a recent life-sciences conference in Sweden, executives of a number of U.S. and foreign biotech companies clashed with Big Pharma in a lively debate on the merits of their respective goals and ...
Biosimilars require a different regulatory framework compared to small-molecule generics. Legislation in the 21st century has addressed this by recognizing an intermediate ground of testing for biosimilars. The filing pathway requires more testing than for small-molecule generics, but less testing than for registering completely new ...
The phrase "drug design" is similar to ligand design (i.e., design of a molecule that will bind tightly to its target). [6] Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, and side effects, that first must be optimized before a ligand can become a safe and effictive drug.
Critics contend that such deals show that Big Pharma doesn't do much R&D, and therefore shouldn’t be charging high prices on drugs. But, Garthwaite said, "The infrastructure to actually take a ...
Why Big Pharma can’t quit the lab monkey business. Erika Fry. January 27, 2024 at 9:00 AM ... Traditionally, companies have used two animal models—one small, like rodents and one large, like a ...