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Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia , including astrocytes and oligodendrocytes .
The progression from neural stem cell to granule cell in the SGZ can be described by tracing the following lineage of cell types: [7] [8] Radial glial cells. Radial glial cells are a subset of astrocytes, which are typically thought of as non-neuronal support cells. The radial glial cells in the SGZ have cell bodies that reside in the SGZ and ...
T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. [5] [6] This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. [5] TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain.
These early stem cells are called neuroepithelial cells (NEC)s, but soon take on a highly elongated radial morphology and are then known as radial glial cells (RGC)s. [3] RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone , which lies adjacent to the central fluid-filled cavity ( ventricular ...
During the formation of the neural tube, neuroepithelial cells undergo symmetric proliferative divisions that give rise to two new neuroepithelial cells. At a later stage of brain development, neuroepithelial cells begin to self renew and give rise to non-stem cell progenitors, such as radial glial cells simultaneously by undergoing asymmetric ...
Radial glial cells extend processes from their soma in the avian ventricular zone to the parenchyma of the adult forebrain. [46] These New neurons have been observed as early as 3 days after thymidine administration in the HVC [ 47 ] and as early as 7 days before reaching the hippocampus. [ 42 ]
Neural stem cells are more specialized than ESCs because they only generate radial glial cells that give rise to the neurons and to glia of the central nervous system (CNS). [4] During the embryonic development of vertebrates, NSCs transition into radial glial cells (RGCs) also known as radial glial progenitor cells, (RGPs) and reside in a ...
The Protomap is a primordial molecular map of the functional areas of the mammalian cerebral cortex during early embryonic development, at a stage when neural stem cells are still the dominant cell type. [1] The protomap is a feature of the ventricular zone, which contains the principal cortical progenitor cells, known as radial glial cells.