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150 mg/day or 200 mg twice daily Finasteride: Propecia: 5αR inhibitor: Oral: 1–5 mg/day Dutasteride: Avodart: 5αR inhibitor: Oral: 0.25–0.5 mg/day Progesterone: Prometrium [c] Progestogen: Oral: 100–400 mg/day Medroxyprogesterone acetate: Provera: Progestogen: Oral: 2.5–40 mg/day Depo-Provera: Progestogen: IM: 150 mg every 3 mos: Depo ...
There is a case report of progesterone misuse with an oral dosage of 6,400 mg per day. [137] Administration of as much as 500 mg progesterone by intravenous infusion in humans was uneventful in terms of toxicity, but did induce deep sleep, though the individuals were still able to be awakened with sufficient stimulation. [119] [17] [120] [121]
Two types of female oral contraceptive pill, taken once per day, are widely available: The combined oral contraceptive pill contains estrogen and a progestin; colloquially known as "the Pill". The progestogen-only pill, colloquially known as "minipill". For perfect use it is 99% effective and typical use is 91% effective.
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
For comparison to MPA, the dosage of progesterone required to inhibit ovulation is 300 mg/day, whereas that of the 19-nortestosterone derivatives norethisterone and norethisterone acetate is only 0.4 to 0.5 mg/day.
[8] [9] [32] Megestrol acetate is an effective contraceptive by itself at dosages of 0.35 to 0.5 mg/day, but is not effective at a dosage of 0.25 mg/day. [7] Megestrol acetate alone does not inhibit ovulation at a dosage of 0.5 mg/day, nor does it fully inhibit ovulation at a dosage of 0.7 mg/day or even at a dosage of 5 mg/day.
It has effects similar to those of the hormone progesterone. [7] As a contraceptive, it works primarily by preventing ovulation and closing off the cervix to prevent the passage of sperm. [7] The endometrial transformation dose of levonorgestrel is 150 to 250 μg/day or 2.5 to 6 mg per cycle. [4] [49] [50] [51]
NETA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [1] It has weak androgenic and estrogenic activity and no other important hormonal activity. [1] [8] The medication is a prodrug of norethisterone in the body. [9] [10]