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The application of positive pressure may be intended to prevent upper airway collapse, as occurs in obstructive sleep apnea, or to reduce the work of breathing in conditions such as acute decompensated heart failure. CPAP therapy is highly effective for managing obstructive sleep apnea.
Positive airway pressure (PAP) is a mode of respiratory ventilation used in the treatment of sleep apnea.PAP ventilation is also commonly used for those who are critically ill in hospital with respiratory failure, in newborn infants (), and for the prevention and treatment of atelectasis in patients with difficulty taking deep breaths.
In December 2024, the FDA approved tirzepatide, an anti-diabetic and weight loss medication, as a component in the combination treatment of adults with obesity suffering from moderate to severe obstructive sleep apnea. Other components of the therapy are a reduced-calorie diet and increased physical activity. [101]
Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and is characterized by recurrent episodes of complete or partial obstruction of the upper airway leading to reduced or absent breathing during sleep.
The respiratory disturbance index (RDI)—or respiratory distress Index—is a formula used in reporting polysomnography (sleep study) findings. Like the apnea-hypopnea index (AHI), it reports on respiratory distress events during sleep, but unlike the AHI, it also includes respiratory-effort related arousals (RERAs). [1]
Nasal expiratory positive airway pressure (Nasal EPAP) is a treatment for obstructive sleep apnea (OSA) and snoring. [1] [2]Contemporary EPAP devices have two small valves that allow air to be drawn in through each nostril, but not exhaled; the valves are held in place by adhesive tabs on the outside of the nose. [1]