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5757 19231 Ensembl ENSG00000187514 ENSMUSG00000026238 UniProt P06454 P26350 RefSeq (mRNA) NM_001099285 NM_002823 NM_008972 RefSeq (protein) NP_001092755 NP_002814 NP_032998 NP_001347759 NP_001347760 Location (UCSC) Chr 2: 231.71 – 231.71 Mb Chr 1: 86.53 – 86.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thymosin α 1 is a peptide fragment derived from prothymosin alpha, a ...
Fraction 5 was found to contain over 40 small peptides (molecular weights ranging from 1000 to 15,000 Da.), [4] which were named "thymosins" and classified as α, β and γ thymosins on the basis of their behaviour in an electric field. Although found together in Fraction 5, they are now known to be structurally and genetically unrelated.
This structure, mostly alpha helix, was artificially stabilised by an organic solvent. [2] The thymosin illustrated, originally named β 9 is the cow orthologue of human β 10 Beta thymosins are a family of proteins which have in common a sequence of about 40 amino acids similar to the small protein thymosin β 4 .
Peptide therapeutics are peptides or polypeptides (oligomers or short polymers of amino acids) which are used to for the treatment of diseases. Naturally occurring peptides may serve as hormones , growth factors , neurotransmitters , ion channel ligands , and anti-infectives ; peptide therapeutics mimic such functions.
The actual T cell receptor is composed of two separate peptide chains, which are produced from the independent T cell receptor alpha and beta (TCRα and TCRβ) genes. The other proteins in the complex are the CD3 proteins: CD3εγ and CD3εδ heterodimers and, most important, a CD3ζ homodimer, which has a total of six ITAM motifs.
7114 n/a Ensembl ENSG00000205542 n/a UniProt P62328 n/a RefSeq (mRNA) NM_021109 n/a RefSeq (protein) NP_066932 n/a Location (UCSC) Chr X: 12.98 – 12.98 Mb n/a PubMed search n/a Wikidata View/Edit Human Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. Recommended INN (International Nonproprietary Name) for thymosin beta-4 is 'timbetasin', as published by the World ...
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...
Checkpoint inhibitor therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints , key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.