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With the use of direct immunofluorescence examination, the specificity of cytology for diagnosing pemphigus can be increased from 43% to 100%. Erythema multiforme, Toxic epidermal necrolysis Apoptotic and necrotic cells, absence of acantholytic cells A Tzanck smear may be a rapid test to distinguish toxic epidermal necrolysis from SSSS III.
A micrograph of an exfoliative cytopathology specimen (Pap test, Pap stain). In this method, cells are collected after they have been either spontaneously shed by the body ("spontaneous exfoliation"), or manually scraped/brushed off of a surface in the body ("mechanical exfoliation").
A Candida yeast infection can also be identified by a KOH test by taking scrapings from the mouth (oral thrush), vagina and skin (candidiasis). There are over 40 different fungus species known to cause disease in humans, of which Candida albicans is the most common and most frequently tested for.
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Brush biopsy/exfoliative cytology is an alternative to incisional biopsy, [5] where a stiff brush is scraped against the lining of the mouth to remove a sample of cells. This is then made into a smear which can be examined microscopically.
Extracellular substances, such as free mucin, colloid, and ground substance, are also easily stained, and appear metachromatic. Major applications include blood smears , bone marrow aspirates, semen analysis and cytology of various body fluids including urine and cerebrospinal fluid .
The Bethesda system (TBS), officially called The Bethesda System for Reporting Cervical Cytology, is a system for reporting cervical or vaginal cytologic diagnoses, [1] used for reporting Pap smear results. It was introduced in 1988 [2] and revised in 1991, [3] 2001, [1] [4] [5] and 2014. [6]
The Papanicolaou test (abbreviated as Pap test, also known as Pap smear (AE), [1] cervical smear (BE), cervical screening (BE), [2] or smear test (BE)) is a method of cervical screening used to detect potentially precancerous and cancerous processes in the cervix (opening of the uterus or womb) or, more rarely, anus (in both men and women). [3]