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Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. [4]It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and a β (beta) subunit that is unique to hCG.
Human chorionic gonadotropin (hCG), progesterone, 17β-estradiol, endorphins and gonadotropin-releasing hormone (GnRH) synthesis are rapidly upregulated by the developing embryo following fertilization of the ovum. [1] [2] [3] During early embryonic development, paracrine/juxtacrine signaling of hCG induces blastulation and neurulation.
Final maturation induction and release, such as by human chorionic gonadotropin (HCG or hCG) or recombinant luteinizing hormone, results in a predictable time of ovulation, with the interval from drug administration to ovulation depending on the type of drug.
The main medications used for induction of final maturation are human chorionic gonadotropin (hCG) and GnRH agonist. In fresh (rather than frozen) autologous cycles of in vitro fertilization, final oocyte maturation triggering with GnRH agonist instead of hCG decreases the risk of ovarian hyperstimulation syndrome but decreases live birth rate.
Using low dose human chorionic gonadotropin (hCG) to replace FSH during the late follicular phase in women undergoing hyperstimulation as part of IVF may make little or no difference to pregnancy rates, and possibly leads to in an equivalent number of oocytes retrieved, but with less expenditure of FSH. [22]
Usually, ovarian stimulation is used in conjunction with ovulation induction to stimulate the formation of multiple oocytes. [35] Some sources [35] include ovulation induction in the definition of ovarian stimulation. A low dose of human chorionic gonadotropin (HCG) may be injected after completed ovarian stimulation. Ovulation will occur ...
3973 16867 Ensembl ENSG00000138039 ENSMUSG00000024107 UniProt P22888 P30730 RefSeq (mRNA) NM_000233 NM_013582 NM_001364898 RefSeq (protein) NP_000224 NP_038610 NP_001351827 Location (UCSC) Chr 2: 48.69 – 48.76 Mb Chr 17: 89.02 – 89.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin ...
Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene. [5]The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently.