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Waldenström macroglobulinemia (/ ˈ v æ l d ən s t r ɒ m ˌ m æ k r oʊ ˌ ɡ l ɒ b j ə l ɪ ˈ n iː m i ə / VAL-dən-strom MAK-roh-GLOB-yə-lin-EE-mee-ə, [1] [2] US also / ˈ v ɑː l d ən s t r ɛ m-/ VAHL-dən-strem - [3]) is a type of cancer affecting two types of B cells: lymphoplasmacytoid cells and plasma cells.
Bing–Neel syndrome (BNS) is an extremely rare neurologic complication of Waldenström macroglobulinemia (WM), which is a chronic lymphoproliferative disorder. [1] There's no clear definition of BNS but what is known so far is that unlike WM, It involves the central nervous system (CNS), infiltrated by differentiated malignant B cells and by having hyperglobulinemia. [2]
Ibrutinib is indicated for the treatment of mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), Waldenström's macroglobulinemia (WM), marginal zone lymphoma (MZL), and chronic graft versus host disease (cGVHD).
The condition was first described in 1909 by Danish ophthalmologist Christian Frederick Heerfordt, for whom the syndrome is now named. [6] It was originally attributed to mumps, but after further studies by Swedish doctor Jan G. Waldenström in 1937, it was classified as a distinct manifestation of sarcoidosis.
Louis Walsh has revealed that he was diagnosed with a rare type of cancer during lockdown.. The former X Factor judge, 71, is currently appearing on Celebrity Big Brother and spoke about his ...
Treatment is highly individualized and depends on a range of factors, including the subtype of the disease, its stage, the patient's age, and other medical conditions. [17] Patients with early-stage indolent lymphoma may be cured with radiation therapy, but most patients have widespread disease at the time of diagnosis. There are many effective ...
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