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Intermediate mesoderm or intermediate mesenchyme is a narrow section of the mesoderm (one of the three primary germ layers) located between the paraxial mesoderm and the lateral plate of the developing embryo. [1] The intermediate mesoderm develops into vital parts of the urogenital system (kidneys, gonads and respective tracts).
The mesoderm moves to the midline until it covers the notochord. When the mesoderm cells proliferate, they form the paraxial mesoderm. In each side, the mesoderm remains thin, and is known as the lateral plate. The intermediate mesoderm lies between the paraxial mesoderm and the lateral plate.
Paraxial mesoderm, also known as presomitic or somitic mesoderm, is the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites , blocks of tissue running along both sides of the neural tube, which form muscle and the tissues of the back, including ...
Mesoderm embryonic tissues (paraxial mesoderm, intermediate mesoderm, lateral plate mesoderm and notochord). Also showing the neural tube and the yolk sac.
The mesoderm germ layer forms in the embryos of triploblastic animals. During gastrulation, some of the cells migrating inward contribute to the mesoderm, an additional layer between the endoderm and the ectoderm. [9] The formation of a mesoderm leads to the development of a coelom. Organs formed inside a coelom can freely move, grow, and ...
The lateral plate mesoderm is separated from the paraxial mesoderm by a narrow region of intermediate mesoderm. The mesoderm is the middle layer of the three germ layers, between the outer ectoderm and inner endoderm. During the third week of embryonic development the lateral plate mesoderm splits into two layers forming the intraembryonic coelom.
The intermediate mesoderm gives rise to the urogenital tract and consists of cells that migrate from the middle region of the primitive line. Other cells migrate through the caudal part of the primitive line and form the lateral mesoderm, and those cells migrating by the most caudal part contribute to the extraembryonic mesoderm. [11] [15]
In the mouse gonadal primordium, the genital ridge, which forms from intermediate mesoderm, becomes morphologically distinct at E10.5. By E12, sexual differentiation of the gonad is apparent, indicating that genes involved in the formation of the bipotential gonad are expressed before E10.5 and E12.