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Orthogonal protection is a strategy allowing the specific deprotection of one protective group in a multiply-protected structure. For example, the amino acid tyrosine could be protected as a benzyl ester on the carboxyl group, a fluorenylmethylenoxy carbamate on the amine group, and a tert -butyl ether on the phenol group.
Different thiol protecting groups provide multiple dimensions of orthogonal protection. These orthogonally protected cysteines are incorporated during the solid-phase synthesis of the peptide. Successive removal of these groups, to allow for selective exposure of free thiol groups, leads to disulfide formation in a stepwise manner.
C3adesArg is more commonly named ASP or acylation-stimulating-protein due to its marked stimulating action on triacylglycerol synthesis in human adipocytes and skin fibroblasts. [2] ASP is also known for its augmentation of glucose transport and inhibiting action on hormone-sensitive lipase .
Orthogonal ligand-protein pairs (also known as re-engineered ligand-receptor interfaces or re-engineered enzyme-substrate interactions) are a protein-ligand binding pair made to be independent of the original binding pair. This is done by taking a mutant protein (naturally occurring or selectively engineered), which is activated by a different ...
Orthographic projection (also orthogonal projection and analemma) [a] is a means of representing three-dimensional objects in two dimensions.Orthographic projection is a form of parallel projection in which all the projection lines are orthogonal to the projection plane, [2] resulting in every plane of the scene appearing in affine transformation on the viewing surface.
Flu vaccines protect against a set of influenza A and B variants every year, the experts say. "Every year, the community, including groups from CDC, work hard to do surveillance worldwide and ...
Melanotan II acts as a non-selective agonist of the melanocortin receptors MC 1, MC 3, MC 4, and MC 5. [4]Melanotan II produces melanogenesis by activation of the MC 1 receptor, whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC 4 receptor (though the MC 3 is thought to also possibly be involved).
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