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The kidney excretion allows levels of over an estimated 5000 pg/ml where it swirtcjhes to liver mostly in the bile. That 2000pg/ml represents a total of 10-20mcg in your, serum, TOTAL. When a person has an IM injection of 1mg of B12, serum level peaks 30 minutes later at approximately 100,000 to 150,000 pg/ml.
I have elevated homocysteine levels however my folate is in the high normal range and my B12 is over 1600. I have several methylation mutations. +/+ SOD2 NAT1 COMT MTRR CBS MTHFD1L TCN2 +/-VDR TAQ/BSM MTHFR C677T/A1298C BHMT GSTP1 GSTM1 ACE AGT DAO FOLR1 FUT2 GAD1 NOS3 PEMT SOD3 and GSTT1 is present My understanding is MTHFR should make me ...
Freddd said: Abnormally high b12 in the absence of supplementation that would cause it to be high often indicates liver damage and that perhaps the liver cells are dying and releasing they cobalamin to the blood. I agree with Fredd. One often ignored cause of liver problems is viral hepatitis.
What dosage of Vitamin D to take, depends on the size of the person, and if they are overweight, the bigger they are the more they need, recent research estimates that the average healthy person will use 3 to 5 thousand IU a day. So 2500 iu is probably not enough to maintain levels, especially if you are using more vitamin D because you are sick.
1,401. Lynn_M said: B12 tests are a poor indicator of B12 levels in the body because they measure both the active transcobalamin form of B12 and the inactive haptocorrin form of B12, which is the used up, spent form. If you have a high haptocorrin level, you could have a high B12 level and still be low in transcobalamin.
Yes, that is perfectly safe. It is quite common that blood levels go through the roof when you supplement with b12, and they may stay high for months or even years. Treatment with b12 must be evaluated by symptoms, not by blood levels.
Re your high B12 - my level is very very high. But it doesn't mean I have too much B12, it means my body is not using it properly. So I take a lot of B12 and hope some of it gets to where it needs to be. I hope you get some answers here!
The latter would account for the buildup of B12 in your blood. The buildup of folate in your blood may be largely folic acid, and you may be one of the people who are not able to convert folic acid to the chemically reduced forms of folate very rapidly, for genetic reasons involving the DHFR enzyme." #6. Jan 26, 2013.
It sounds like B12 deficiency only has pretty vague symptoms, but folate has a few according to wikipedia, and B6 can include quite a few as well. Some symptoms (MSG/E621 induced migraines, seborrhoeic dermatitis, intertrigo) I've had for over a decade prior to getting M.E.!
A red blood cell test (RBC) would be a more accurate way of finding out whether the B12 is actually getting in to the cells. if B12 cellular uptake is very low, despite the seemingly high blood level, then B6 will also be high because B6 needs active B12 in order to be metabolised, as I understand it. #11. Oct 31, 2020.