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Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent , and gadolinium (Gd 3+ ), and is used in form of the meglumine salt (gadoterate meglumine).
Patients who have experienced a previous adverse reaction to another contrast agent, have bronchial asthma, and/or allergic disorders have an increased risk of a hypersensitivity reaction to gadobutrol. Hypersensitivity reactions can include anaphylactoid and anaphylactic reactions ranging from mild to severe.
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DOTA is derived from the macrocycle known as cyclen.The four secondary amine groups are modified by replacement of the N-H centers with N-CH 2 CO 2 H groups. The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations.
Patients with severely deteriorated kidney function are more at risk for NSF, with dialysis patients being more at risk than patients with mild chronic kidney disease. [ 21 ] [ 22 ] NSF can be caused by linear and macrocyclic [ 23 ] [ 24 ] (macrocyclic ionic compounds have been found the least likely to release the Gd 3+ ), [ 25 ] [ 17 ...
Anti-cancer psychotherapy – a technique [131] claiming that a "cancer personality" caused cancer, which could be cured through talk therapy (e.g. that of the Simonton Cancer Center, [132] Bernie Siegel's "Exceptional Cancer Patients" (ECaP) or Deepak Chopra). Evidence is lacking that cancer cures sold or promoted by Deepak Chopra have any value.