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Eplerenone is an antimineralocorticoid, or an antagonist of the mineralocorticoid receptor (MR). [21] Eplerenone is also known chemically as 9,11α-epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone and "was derived from spironolactone by the introduction of a 9α,11α-epoxy bridge and by substitution of the 17α-thoacetyl ...
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Potassium-sparing diuretics act to prevent sodium reabsorption in the collecting tubule by either binding ENaCs (amiloride, triamterene) or by inhibiting aldosterone receptors (spironolactone, eplerenone). This prevents excessive excretion of K + in urine and decreased retention of water, preventing hypokalemia. [10]
There’s no best time to take metformin for weight loss or type 2 diabetes (or any other condition). But taking it at the same time each day can help you stay consistent and avoid missing or ...
Eplerenone, a steroidal antimineralocorticoid of the spirolactone group; Estriol triacetate, an estrogen medication and an estrogen ester
Light on dark color schemes require less energy to display on OLED displays. This positively impacts battery life and reduces energy consumption. [16]While an OLED will consume around 40% of the power of an LCD displaying an image that is primarily black, it can use more than three times as much power to display an image with a white background, such as a document or web site. [17]
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Combination of; Ethinylestradiol: Estrogen: Drospirenone: Progestogen; Progestin; Antimineralocorticoid; Antiandrogen: Clinical data; Trade names: With 30 μg ...