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The hepatitis B virion, is a complex, spherical, double shelled particle with a diameter of 42 nm. [1] [2] [3]The 6 nm [2] thick outer viral envelope or membrane contains host-derived lipids and surface proteins, [2] known collectively as HBsAg. [3]
The structure of the Hepatitis B virus as first described by Dane & al. [1] and Jokelainen, Krohn & al. [2] during 1970. The hepatitis B virion is a complex, double shelled, spherical particle with a 42 nm diameter. [1] [2] [3] The 6 nm [2] thick outer viral envelope or membrane contains host-derived lipids and surface proteins, [2] known ...
A simplified drawing of the HBV particle and surface antigen. Purple = Lipid Envelope, Red = Nucleocapsid Core (Note: This drawing is slightly misleading in that the nucleocapsid core is a single entity even though it is depicted as a light blue icosahedral line shape and a red ring of circles). The genome organisation of HBV. The genes overlap.
The structure of hepatitis B virus. Hepatitis B virus is a member of the Hepadnavirus family. [11] The virus particle, called Dane particle [12] (), consists of an outer lipid envelope and an icosahedral nucleocapsid core composed of protein.
Hepatitis B virus replication. The life cycle of hepatitis B virus is complex. Hepatitis B is one of a few known pararetroviruses: non-retroviruses that still use reverse transcription in their replication process. The virus gains entry into the cell by binding to NTCP [51] on the surface and being endocytosed. Because the virus multiplies via ...
HBcAg (core antigen) is a hepatitis B viral protein. [ 1 ] [ 2 ] It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).
Viral replication is nucleo-cytoplasmic. Replication follows the dsDNA(RT) replication model. DNA-templated transcription, specifically dsDNA(RT) transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by budding, and nuclear pore export.