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Cells also contain anion antiporters such as the Band 3 (or AE1) anion transport protein. This cotransporter is an important integral protein in mammalian erythrocytes and moves chloride ion and bicarbonate ion in a one-to-one ratio across the plasma membrane based only on the concentration gradient of the two ions.
The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. [1] In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes (SLC12A2 and SLC12A1 respectively). Two isoforms of the NKCC1/Slc12a2 gene ...
Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. The energy stored in an inwardly directed electrochemical sodium gradient, the sodium-motive force (SMF) is used to drive solute accumulation against a concentration gradient.
The transport of glucose across the proximal tubule cell membrane involves a complex process of secondary active transport (also known as co-transport). [3] This process begins with the Na + /K + ATPase on the basolateral membrane. This enzyme uses ATP to pump 3 sodium ions out of the cell into the blood while bringing 2 potassium ions into the ...
In terms of membrane transport the gradient is of interest as it contributes to decreased system entropy in the co-transport of substances against their gradient. One of the most important pumps in animal cells is the sodium potassium pump, that operates through the following mechanism: [9]
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The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), [5] is a protein that in humans is encoded by the SLC5A5 gene. [6] [7] [8] It is a transmembrane glycoprotein with a molecular weight of 87 kDa and 13 transmembrane domains, which transports two sodium cations (Na +) for each iodide anion (I −) into the cell. [9]
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