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It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
While studying under W. E. Castle, Little began his work with mice, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. In 1921, he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. [2]
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
B16 cells were discovered and maintained in the Jackson Laboratories in Maine in 1954 when a tumor developed naturally behind the ear of a C57BL/6 mouse. [2] The cells were resected, transplanted, and maintained in vivo, and still are today.
To create a coisogenic strain through breeding, a mouse with the specific mutation on a locus is mated to an inbred strain (e.g., C57BL/6J) mouse. The offspring of the mutated mouse with the inbred strain has a 50% chance of carrying the mutation. From this, the offspring with the mutation can be mated to a heterozygous carrier which then ...
The first set of eight strains, the CXB family, were generated by Donald Bailey at the Jackson Laboratory from an intercross between a female BALB/cBy mouse (abbreviated C) and a male C57BL/6By mouse in the 1960s.
As the first model organisms were introduced into labs in the 20th century, these early efforts to identify standards to measure organisms against persisted. Beginning in the early 1900s Drosophila entered the research laboratories and opened up the doors for other model organisms like tobacco mosaic virus, E. coli, C57BL/6 (lab mice), etc ...