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The virus causes measles, a highly contagious disease transmitted by respiratory aerosols that triggers a temporary but severe immunosuppression.Symptoms include fever, cough, runny nose, inflamed eyes and a generalized, maculopapular, erythematous rash and a pathognomonic Koplik spot seen on buccal mucosa opposite to lower 1st and 2nd molars.
Viruses may undergo two types of life cycles: the lytic cycle and the lysogenic cycle. In the lytic cycle, the virus introduces its genome into a host cell and initiates replication by hijacking the host's cellular machinery to make new copies of the virus. [12] In the lysogenic life cycle, the viral genome is incorporated into the host genome.
Replication of the canine distemper virus (CDV) cycle. Viral replication is cytoplasmic. Entry into the host cell is achieved by viral attachment to host cell. Replication and transcription follow the negative-stranded RNA virus models. [7] Translation takes place by leaky scanning, ribosomal shunting, and RNA termination-reinitiation. The ...
Influenza virus replication cycle. Replication of −ssRNA genomes is executed by RdRp, which initiates replication by binding to a leader sequence on the 3'-end (usually pronounced "three prime end") of the genome. RdRp then uses the negative sense genome as a template to synthesize a positive-sense antigenome.
An electron micrograph of the measles virus. Measles is caused by the measles virus, a single-stranded, negative-sense, enveloped RNA virus of the genus Morbillivirus within the family Paramyxoviridae. [51] The virus is highly contagious and is spread by coughing and sneezing via close personal contact or direct contact with secretions. [52 ...
Typical sites of virus entry into the body: The first steps of viral infection is determined by the site at which the virus implants into the body. This would subsequently dictate the mechanisms of viral pathogenesis. Transmission from a host with an infection to a second host; Entry of the virus into the body; Local replication in susceptible ...
Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaching to host cell. Replication follows the negative-stranded RNA virus replication model. Negative-stranded RNA virus transcription, using polymerase stuttering, through co-transcriptional RNA editing is the method of transcription. Translation takes place by ...
Genome type and replication cycle of different RNA viruses. RNA viruses in Orthornavirae typically do not encode many proteins, but most positive-sense, single-stranded (+ssRNA) viruses and some double-stranded RNA (dsRNA) viruses encode a major capsid protein that has a single jelly roll fold, so named because the folded structure of the protein contains a structure that resembles a jelly ...