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Salicylate intolerance is a form of food intolerance or of drug intolerance. Salicylate sensitivity is a pharmacological reaction, not a true IgE -mediated allergy . However, it is possible for aspirin to trigger non-allergic hypersensitivity reactions.
The test has a sensitivity of 94% and a specificity of 74% for identifying patients whose salicylate concentrations are greater than 30 mg per decilitre (2.17 mmol/L). [1] False positive concentrations (2.8 to 14.3 mg per decilitre) have been reported to occur in neonates with hyperbilirubinemia , premature neonates, and children who are ...
Salicylate testing is a category of drug testing that is focused on detecting salicylates such as acetysalicylic acid for either biochemical or medical purposes.
About 50–80% of salicylate in the blood is bound to human serum albumin, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1–0.2 L/kg.
The 'worst-case' sensitivity or specificity must be calculated in order to avoid reliance on experiments with few results. For example, a particular test may easily show 100% sensitivity if tested against the gold standard four times, but a single additional test against the gold standard that gave a poor result would imply a sensitivity of ...
Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]
Celiac disease, an autoimmune disorder caused by an immune response to the protein gluten, results in gluten intolerance and can lead to temporary lactose intolerance. [ 27 ] [ 28 ] The most widely distributed naturally occurring food chemical capable of provoking reactions is salicylate , [ 18 ] although tartrazine and benzoic acid are well ...
Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).