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The connecting peptide, or C-peptide, is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecule. In the context of diabetes or hypoglycemia, a measurement of C-peptide blood serum levels can be used to distinguish between different conditions with similar clinical features.
The signal peptide sequence is removed in the endoplasmic reticulum, yielding a propeptide. The propeptide travels to the Golgi apparatus where it is proteolytically cleaved and processed into multiple peptides. Peptides are packaged into dense core vesicles, where further cleaving and processing, such as C-terminal amidation, can occur.
A peptidergic agent (or drug) is a chemical which functions to directly modulate the peptide systems in the body or brain. An example is opioidergics, which are neuropeptidergics. A cell-penetrating peptide is a peptide able to penetrate the cell membrane.
Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier into the brain.This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
Carboxypeptidase E functions in the production of nearly all neuropeptides and peptide hormones. The enzyme acts as an exopeptidase to activate neuropeptides . It does that by cleaving off basic C-terminal amino acids, producing the active form of the peptide.
The hormone peptide YY is released by your GI (gastrointestinal) tract when you eat protein and fat. It acts on the appetite centers in your brain, helping your food intake stay in check by ...
Substance P and the NK1-receptor are widely distributed in the brain and are found in brain regions that are specific to regulating emotion (hypothalamus, amygdala, and the periaqueductal gray). [12] They are found in close association with serotonin (5-HT) and neurons containing norepinephrine that are targeted by the currently used ...
Trump often used “Y.M.C.A.” at events for his presidential campaigns. In December 2024, Willis shared on social media that he had received over 1,000 complaints about Trump’s usage of the song.