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With nontreponemal tests, false-positive reactions can occur for a large number of reasons, the most common of which is other infections, both viral and bacterial. Additionally these tests may show false-negative when the patient's antibody titer is very high due to a hook effect (also called a prozone effect).
The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly
Latent syphilis has no symptoms and can last years. [2] In tertiary syphilis, there are gummas (soft, non-cancerous growths), neurological problems, or heart symptoms. [3] Syphilis has been known as "the great imitator", because it may cause symptoms similar to many other diseases. [2] [3] Syphilis is most commonly spread through sexual ...
The rise in syphilis cases can be partially attributed to a lack of sexual education, one expert says. ... a positive result should be followed up with a visit to a medical professional in order ...
Syphilis is usually spread from direct contact with a syphilis sore during vaginal, anal or oral sex, according to the CDC, although it can also spread from an infected pregnant women to her ...
For primary syphilis, TPPA has a sensitivity of 85% to 100%, and a specificity of 98% to 100%. [2] In secondary and late-latent syphilis, TPPA has a sensitivity of 98% to 100%. [2] Antibodies against other treponemal organisms, such as the T. pallidum subspecies endemicum, pertenue, or carateum, can cause false positive
A new proven protocol in which doxycycline is used to prevent sexually transmitted infections — called doxyPEP — has been an apparent sleeper hit among gay and bisexual men.
Also, patients who have certain antiphospholipid antibodies may have false positive VDRL test, which aims to detect a syphilis infection. This occurs because the aPL bind to the lipids in the test and make it come out positive. A more specific test for syphilis, FTA-Abs, will not have a false-positive result in the presence of aPL. [citation ...