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Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease , gastroesophageal reflux disease , and Zollinger-Ellison syndrome . [ 4 ]
Skeletal formula of famotidine. Unlike cimetidine, famotidine has no significant interactions with other drugs. With regard to pharmacokinetics, cimetidine in particular interferes with some of the body's mechanisms of drug metabolism and elimination through the liver cytochrome P450 (CYP) pathway.
Gastro-esophageal reflux disease during pregnancy—First-line drug therapy combined with lifestyle and diet modification. [ 17 ] Stress ulcer prophylaxis —The use of sucralfate rather than H 2 antagonists for stress ulcer prophylaxis, and measures to prevent aspiration , such as continuous subglottic suctioning, have been shown to reduce the ...
Ibuprofen/famotidine, sold under the brand name Duexis, is a fixed-dose combination medication used for the treatment of rheumatoid arthritis and osteoarthritis. [1] It contains ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) and famotidine, a histamine H2-receptor antagonist. [1] Ibuprofen/famotidine is available as a generic ...
Subsequent to the introduction onto the U.S. drug market, two other H 2 receptor antagonists were approved, ranitidine (Zantac, Glaxo Labs) and famotidine (Pepcid, Yamanouchi, Ltd.) Cimetidine became the first drug ever to reach more than $1 billion a year in sales, thus making it the first blockbuster drug. [citation needed]
[55] [57] An interaction between PPIs and the metabolism of the platelet inhibitor clopidogrel is known and this drug is also often used in people with cardiac disease. [ 58 ] [ 59 ] [ 22 ] There are associations with an increased risk of stroke, but this appears to be more likely to occur in people who already have an elevated risk.
Lisuride is a ligand of dopamine, serotonin, and adrenergic receptors as well as the histamine H 1 receptor. [4] It has sub-nanomolar affinity for the dopamine D 2, and D 3 receptors, serotonin 5-HT 1A and 5-HT 1D receptors, and α 2A-, α 2B-, and α 2C-adrenergic receptors, and low-nanomolar affinity for the dopamine D 1, D 4, and D 5 receptors, serotonin 5-HT 2A, 5-HT 2B, and 5-HT 2C ...
Flufenamic acid is a highly polymorphic drug molecule with multiple structurally characterized polymorphic modifications. [4] It has a unique chemical structure and stands out among fenamates. [ 5 ] Nowadays, eight polymorphic forms are known that are determined by different conformers, [ 6 ] [ 7 ] which makes flufenamic acid unique among other ...