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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, especially those under 3 years old.
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
Trilateral retinoblastoma (TRb) is a malignant midline primitive neuroectodermal tumor occurring in patients with inherited uni- or bilateral retinoblastoma.In most cases trilateral retinoblastoma presents itself as pineoblastoma (pineal TRb).
Retinoblastoma - Strabismus (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. Retinoblastoma can occur in one or both eyes. This tumor occurs in babies and young children. It is called RB for short.
In non-inherited retinoblastoma, instead two mutations, or "hits", had to take place before a tumor could develop, explaining the later onset. It was later found that carcinogenesis (the development of cancer) depended both on the mutation of proto-oncogenes (genes that stimulate cell proliferation ) and on the inactivation of tumor suppressor ...
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
Thaddeus P. Dryja is an American ophthalmologist and geneticist known for his role in the 1986 discovery of the retinoblastoma (Rb) tumor suppressor gene. [1] and the 1990 discovery of mutations in the rhodopsin gene as the cause of autosomal dominant retinitis pigmentosa (the first identified gene for non-syndromic retinitis pigmentosa).
Retinoblastoma is a rare form of eye neoplasm (found in the retina) that is mostly found in children, being the most common intraocular malignancy of infancy and childhood. The incidence is of one case per every 15,000 to 20,000 live births, and some of the most common symptoms of this disease are leukocoria and strabismus, iris rubeosis ...