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This registry based, multi-center, multi-country data provide provisional support for the use of ECMO for COVID-19 associated acute hypoxemic respiratory failure. Given that this is a complex technology that can be resource intense, guidelines exist for the use of ECMO during the COVID-19 pandemic. [85] [86] [87]
Mortality at 60 days was the primary endpoint. The calculated sample size was 331 patients with an intent to show a 20% reduction in absolute mortality in the ECMO group. The main secondary endpoint was treatment failure – cross-over to ECMO due to refractory hypoxemia or death in the control group and death in the ECMO group.
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Robert Bartlett (born May 8, 1939) is an American physician and medical researcher who is credited with developing a lifesaving heart-lung technology known as extracorporeal membrane oxygenation (ECMO). He is an emeritus professor of surgery at the University of Michigan Medical School.
Human coronavirus OC43 [1] (HCoV-OC43) is a member of the species Betacoronavirus 1, which infects humans and cattle. [ 2 ] [ 3 ] The infecting coronavirus is an enveloped , positive-sense , single-stranded RNA virus that enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor . [ 4 ]
SARS-CoV-2 is the seventh known coronavirus to infect people, after 229E, NL63, OC43, HKU1, MERS-CoV, and the original SARS-CoV. [105] Like the SARS-related coronavirus implicated in the 2003 SARS outbreak, SARS‑CoV‑2 is a member of the subgenus Sarbecovirus (beta-CoV lineage B). [106] [107] Coronaviruses undergo frequent recombination. [108]