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Chloroquine (CQ) then becomes protonated (to CQ 2+), as the digestive vacuole is known to be acidic (pH 4.7); chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme (or FP) to form the FP-chloroquine complex; this ...
A feline zoonosis is a viral, bacterial, fungal, protozoan, nematode or arthropod infection that can be transmitted to humans from the domesticated cat, Felis catus.Some of these diseases are reemerging and newly emerging infections or infestations caused by zoonotic pathogens transmitted by cats.
Feline diseases are often opportunistic and tend to be more serious in cats that already have concurrent sicknesses. Some of these can be treated and the animal can have a complete recovery. Others, like viral diseases, are more difficult to treat and cannot be treated with antibiotics, which are not effective against viruses.
Feline viral rhinotracheitis (FVR) is an upper respiratory or pulmonary infection of cats caused by Feline herpesvirus, also called Feline herpesvirus 1 (FeHV-1), of the family Herpesviridae. It is also commonly referred to as feline influenza , feline coryza , and feline pneumonia but, as these terms describe other very distinct collections of ...
Feline leukemia virus (FeLV) is a retrovirus that infects cats.FeLV can be transmitted from infected cats when the transfer of saliva or nasal secretions is involved. If not defeated by the animal's immune system, the virus weakens the cat's immune system, which can lead to diseases which can be lethal.
Fusobacterium is a genus of obligate anaerobic, Gram-negative, [2] non-sporeforming bacteria [3] belonging to Gracilicutes. Individual cells are slender, rod-shaped bacilli with pointed ends. [ 4 ] [ 5 ] Fusobacterium was discovered in 1900 by Courmont and Cade and is common in the flora of humans.
Chlamydia felis (formerly Chlamydophila felis and before that Chlamydia psittaci var. felis) is a Gram-negative, obligate intracellular bacterial pathogen that infects cats. [2] It is endemic among domestic cats worldwide, primarily causing inflammation of feline conjunctiva , rhinitis and respiratory problems.
The most common colonization site in the human body is within the nasal cavity and from here, the bacteria can cause infections. [ 42 ] [ 43 ] S. pseudintermedius infections in a human host have been known to cause endocarditis, post-surgical infections, inflammation of the nasal cavity ( rhinosinusitis ) and catheter-related bacteremia. [ 6 ]