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Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins.
Some inflammatory cytokines have additional roles such as acting as growth factors. [5] Pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α also trigger pathological pain. [1] While IL-1β is released by monocytes and macrophages, it is also present in nociceptive DRG neurons. IL-6 plays a role in neuronal reaction to an injury.
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system.It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
The fecal immunochemical test (FIT) is a diagnostic technique that examines stool samples for traces of non-visible blood, which could potentially indicate conditions including bowel cancer. [1] Symptoms which could be caused by bowel cancer and suggest a FIT include a change in bowel habit, anaemia, unexplained weight loss, and abdominal pain.
Interleukin-13 has a critical role in goblet cell metaplasia. [12] Goblet cells are filled with mucin (MUC). [12] MUC5AC Mucin 5AC is a gel-like mucin product of goblet cells. [12] Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium.
Faecal calprotectin (or fecal calprotectin) is a biochemical measurement of the protein calprotectin in the stool.Elevated faecal calprotectin indicates the migration of neutrophils to the intestinal mucosa, which occurs during intestinal inflammation, including inflammation caused by inflammatory bowel disease.