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Adaptor protein (AP) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180 , epsins and auxilin ).
Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. [ 1 ] It forms a triskelion shape composed of three clathrin heavy chains and three light chains.
Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes. [1] There are several types of adaptin, each related to a different AP complex.
The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. [1] It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. [5] This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small ...
The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [7]
AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene. [5] [6] [7] One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of ...
11765 Ensembl ENSG00000166747 ENSMUSG00000031731 UniProt O43747 P22892 RefSeq (mRNA) NM_001128 NM_001030007 NM_001301211 NM_009677 RefSeq (protein) NP_001025178 NP_001119 NP_001288140 NP_033807 Location (UCSC) Chr 16: 71.73 – 71.81 Mb Chr 8: 110.51 – 110.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the ...