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7-Methylxanthine (7-MX), also known as heteroxanthine, is an active metabolite of caffeine (1,3,7-trimethylxanthine) and theobromine (3,7-dimethylxanthine). [ 1 ] [ 2 ] It is a non-selective antagonist of the adenosine receptors .
Methylxanthines are chemical compounds which are derivatives of xanthine with one or more methyl groups, including: One methyl group: 1-Methylxanthine; 3-Methylxanthine; 7-Methylxanthine; Two methyl groups: Theophylline (1,3-dimethylxanthine) Paraxanthine (1,7-dimethylxanthine) Theobromine (3,7-dimethylxanthine) Three methyl groups:
The systematic name of this enzyme class is S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase. Other names in common use include monomethylxanthine methyltransferase , MXMT , CTS1 , CTS2 , and S-adenosyl-L-methionine:7-methylxanthine 3-N-methyltransferase .
In enzymology, a N-methyl nucleosidase (EC 3.2.2.25) is an enzyme that catalyzes the chemical reaction. 7-methylxanthosine + H 2 O 7-methylxanthine + D-ribose. Thus, the two substrates of this enzyme are 7-methylxanthosine and H 2 O, whereas its two products are 7-methylxanthine and D-ribose.
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