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Antacids administered in a peptic ulcer regimen may decrease the AUC of a single dose of phenytoin. Patients should be cautioned against concomitant use of antacids and phenytoin." [44] Warfarin and trimethoprim increase serum phenytoin levels and prolong the serum half-life of phenytoin by inhibiting its metabolism. Consider using other ...
Purple glove syndrome is caused by the intravenous anticonvulsant phenytoin. [3] This medication has many already established neurological side effects. However, glove syndrome is a rare, with prevalence ranging from 1.7% to 5.9%, but has very serious adverse effect that may lead to limb amputations.
Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus. Fosphenytoin was developed in 1996.
Phenytoin, a CYP2C9 inducer, would increase its activity and the rate of warfarin breakdown, thereby reducing its efficacy. [23] Patients should avoid the co-administration of warfarin and phenytoin. In cases where both drugs must be used together, warfarin dosing may be titrated up to cope with the reduced efficacy. [24]
Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity). It is more often applied to non-human animals than to humans. In general, it is preferred when large amounts of blood replacement fluids are needed or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection.
Cancers is a peer-reviewed, open access, medical journal published by MDPI covering all fields of oncology. [1] The editor-in-chief is Samuel C. Mok (The University of Texas MD Anderson Cancer Center). The Irish Association for Cancer Research (IACR) and the Signal Transduction Society (STS) are affiliated societies.
[1] [4] Intravenous injection requires a direct injection of high-dose MTX into a patient’s vein; [4] Intrathecal injection, i.e. injection of the drug into the intrathecal space holding cerebrospinal fluid (CSF), is either administered via the Ommaya reservoir, an implanted container passing fluid into the brain, or by lumbar puncture.
Chemically it is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. [11] The poor water solubility of dantrolene leads to certain difficulties in its use. [11] [16] A more water-soluble analog of dantrolene, azumolene, is under development for similar indications. [16]