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Therefore, it is responsible for CRL deneddylation – at the same time, it is able to bind denedyllated cullin-RING complex and retain them in deactivated form. COP9 signalosome thus serves as a sole deactivator of CRLs. [1] The complex was originally identified in plants, [2] [3] and subsequently found in all eukaryotic organisms including human.
10987 26754 Ensembl ENSG00000121022 ENSMUSG00000025917 UniProt Q92905 O35864 RefSeq (mRNA) NM_006837 NM_001277101 NM_013715 RefSeq (protein) NP_006828 NP_006828.2 NP_001264030 NP_038743 Location (UCSC) Chr 8: 67.04 – 67.08 Mb Chr 1: 10.09 – 10.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 ...
The conference included the 9th Conference of the Parties (COP9) to the United Nations Framework Convention on Climate Change (UNFCCC). The parties agreed to use the Adaptation Fund established at COP7 in 2001 primarily in supporting developing countries better adapt to climate change. The fund would also be used for capacity-building through ...
COP9 signalosome complex subunit 8 is a protein that in humans is encoded by the COPS8 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene is the smallest of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways.
COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene. [5] [6] [7] It encodes a subunit of the COP9 signalosome. The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun.
The United Nations Climate Change Conferences are yearly conferences held in the framework of the United Nations Framework Convention on Climate Change (UNFCCC). They serve as the formal meeting of the UNFCCC parties – the Conference of the Parties (COP) – to assess progress in dealing with climate change, and beginning in the mid-1990s, to negotiate the Kyoto Protocol to establish legally ...
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COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene. [5] [6] [7] It encodes a subunit of the COP9 signalosome. Interactions.