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Sertraline has about 60 times more potent inhibition potential on 5-HT than either NE or DA re-uptake. It is possible that only modest inhibition of DAT and NET is needed to cause an increase in energy, motivation and concentration, specially when added to other activity such as SERT inhibition. [18]
Sertraline is highly plasma protein bound (98.5%) across a concentration range of 20 to 500 ng/mL. [5] Despite the high plasma protein binding, sertraline and its metabolite desmethylsertraline at respective tested concentrations of 300 ng/mL and 200 ng/mL were found not to interfere with the plasma protein binding of warfarin and propranolol ...
Sertraline will hopefully help you regain control over your mental health and day-to-day life and you’ll never see this list of side effects again. But if you’re worried or have further ...
The range of possible mechanisms includes (1) nonspecific neurological effects (e.g., sedation) that globally impair behavior including sexual function; (2) specific effects on brain systems mediating sexual function; (3) specific effects on peripheral tissues and organs, such as the penis, that mediate sexual function; and (4) direct or ...
They generally work by targeting neurotransmitters in your brain — like serotonin — to improve your mood. Some antidepressants and anti-anxiety medications include: Selective serotonin ...
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).