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Actinomyces is a genus of the Actinomycetia class of bacteria. They all are Gram-positive and facultatively anaerobic , growing best under anaerobic conditions. [ 2 ] Actinomyces species may form endospores , and while individual bacteria are rod-shaped , Actinomyces colonies form fungus -like branched networks of hyphae . [ 3 ]
Actinomycetales can be found mostly in soil and decaying organic matter, as well as in living organisms such as humans and animals. They form symbiotic nitrogen fixing associations with over 200 species of plants, and can also serve as growth promoting or biocontrol agents, or cause disease in some species of plants.
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic. Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing. However, these classifications are based on laboratory behavior.
Actinomycetota-derived antibiotics that are important in medicine include aminoglycosides, anthracyclines, chloramphenicol, macrolide, tetracyclines, etc. [citation needed] Actinomycetota have high guanine and cytosine content in their DNA. [21] The G+C content of Actinomycetota can be as high as 70%, though some may have a low G+C content. [22]
Scanning electron micrograph of Actinomyces israelii. Scientific classification; Domain: Bacteria: Phylum: Actinomycetota: Class: Actinomycetia (Stackebrandt et al. 1997) Salam et al. 2020 [1] Type genus; Actinomyces
Colonies of a gram-positive pathogen of the oral cavity, Actinomyces sp. In the classical sense, six gram-positive genera are typically pathogenic in humans. Two of these, Streptococcus and Staphylococcus, are cocci (sphere-shaped). The remaining organisms are bacilli (rod-shaped) and can be subdivided based on their ability to form spores.
Streptomyces antibioticus was discovered by Selman Waksman and H. Boyd Woodruff, who named the bacterium Actinomyces antibioticus. [2] In their 1941 publication, Waksman and Woodruff describe their use of the "bacterial-agar plate method", in which they mixed a suspension of E. coli with washed agar containing 1.5% NaCl and 0.5% K 3 PO 4. [2]
Streptomyces is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. [3] Over 700 species of Streptomyces bacteria have been described. [4] [5] [6] As with the other Actinomycetota, streptomycetes are gram-positive, and have very large genomes with high GC content.