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5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2). People with this condition are genetically male, with one X and one Y chromosome in each cell, and they have testes .
5α-Reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength, which has been proposed to be due to lack of 5α-reductase type 1 expression in bone and muscle. [29] In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at puberty. [6]
The transformation of a phenotypically female child into a phenotypically male adult at puberty, which is reported to be celebrated in Dominican culture, is the result of a genotypic male (with XY chromosomes) born with a deficiency in the enzyme 5α-reductase. 5α-Reductase is responsible for the reduction of testosterone to dihydrotestosterone.
An enzyme called 5-alpha reductase converts a small percentage of testosterone into DHT on an ongoing basis. ... Biotin deficiency is a rare health issue that can cause excess hair shedding.
The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), [5] [6] one of three isozymes of 5α-reductase. 5αR2 catalyzes the conversion of the male sex hormone testosterone into the more potent androgen , dihydrotestosterone .
An award-winning California teacher broke down in tears in court as she confessed to sexually abusing two of her students, ages 11 and 12. Jacqueline Ma, who was named “Teacher of the Year” in ...
5α-reductase deficiency (5-ARD) – an autosomal recessive condition caused by a mutation of the 5-alpha reductase type 2 gene. It only affects people with Y chromosomes, namely genetic males. People with this condition are fertile, with the ability to father children, but may be raised as females due to ambiguous or feminized genitalia.
From January 2008 to December 2012, if you bought shares in companies when Patricia Q. Stonesifer joined the board, and sold them when she left, you would have a 163.1 percent return on your investment, compared to a -2.8 percent return from the S&P 500.