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Canavan disease was first described in 1931 by Myrtelle Canavan. [17] In 1931, she co-wrote a paper discussing the case of a child who had died at 16 months old and whose brain had a spongy white section. Canavan was the first to identify this degenerative disorder of the central nervous system, which was later named Canavan disease. [18]
The symptoms in the terminal stage of disease development are sweating, emesis, hyperthermia, seizures, and hypotension, which usually results in the death of the child. [13] Life expectancies of affected infants vary, but most infants do not live past the age of ten. [5] Facial view of an infant with macrocephaly
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In pathology, pathogenesis is the process by which a disease or disorder develops. It can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. [1] The word comes from Ancient Greek πάθος (pathos) 'suffering, disease' and γένεσις (genesis) 'creation'.
Paola Leone is an Italian researcher of Canavan disease, a leukodystrophy. Leone was born and raised in Cagliari, Italy. She received her undergraduate and graduate training in Italy, followed by post-doctoral studies in Montreal and Yale University in New Haven, CT. She holds a doctorate degree in Neuroscience from the University of Padua. [1]
Canavan's research focused on the effects of nervous system damage on the mind and body. She was also very interested in bacteriology; the first of the 79 articles she published was on bacillary dysentery and the first article she co-authored with Southard concerned bacterial invasions of blood and cerebrospinal fluid. [3]
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Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse". [1] In oncology, PFS usually refers to situations in which a tumor is present, as demonstrated by laboratory testing, radiologic testing, or clinically. Similarly ...