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The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; [3] hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine.
Sulfacetamide is a sulfonamide antibiotic, that is used as a cream to treat skin infections and as eye drops to treat eye infections. On the skin it is used to treat acne and seborrheic dermatitis. [1] In cream form it is used to treat bacterial infections on the skin. It can also be used orally to treat urinary tract infections. [2]
Author of The Demon Under the Microscope, a history of the discovery of the sulfa drugs; A History of the Fight Against Tuberculosis in Canada (Chemotherapy) Presentation speech, Nobel Prize in Physiology and Medicine, 1939; The History of WW II Medicine "Five Medical Miracles of the Sulfa Drugs". Popular Science, June 1942, pp. 73–78.
Prontosil is an antibacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria.One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
Since it inhibits bacterial growth, sulfamethoxazole is considered a bacteriostatic antibiotic. [1] Tetrahydrofolate synthesis pathway. Sulfonamides are selective against bacteria because they interfere with the synthesis of folate, a process which does not occur in humans. Humans do not synthesize folate, and must acquire it through diet. [13]
Co-trimoxazole is the recommended standard treatment for whipple's disease in some treatment protocols. [54] [55] [56] Fungal and protozoal infections: Isosporiasis: No: No: No: Clinical trials have confirmed its use in this indication. [57] Malaria: No: No: No: Clinical trials have confirmed its efficacy in both the treatment and prevention of ...
Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized with a sulfonamide group. [ 1 ] Powdered sulfanilamide was used by the Allies in World War II to reduce infection rates and contributed to a dramatic reduction in mortality rates compared to ...
It is a second-line treatment for otitis media, prophylaxis of rheumatic fever, chancroid, chlamydia, and infections by Haemophilus influenzae. [1] It is also used as adjunct therapy for chloroquine-resistant malaria and several forms of bacterial meningitis. [4] It is taken by mouth. [1] Sulfadiazine is available in multiple generic tablets of ...