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  2. DNA polymerase - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase

    A DNA polymerase is a member of a family of enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex. During this process, DNA polymerase ...

  3. DNA polymerase epsilon - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase_epsilon

    DNA polymerase epsilon. DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evidence suggests that it plays a major role in leading strand DNA synthesis and ...

  4. DNA polymerase delta - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase_delta

    DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex consists of 4 subunits: POLD1, POLD2, POLD3, and POLD4. [1] DNA Pol δ is an enzyme used for both leading and lagging strand synthesis. [2][3] It exhibits increased processivity when ...

  5. DNA polymerase alpha - Wikipedia

    en.wikipedia.org/wiki/Polymerase_(DNA_directed...

    DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2. [2] Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it is not well suited ...

  6. DNA polymerase III holoenzyme - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase_III_holoenzyme

    This is the old textbook "trombone model" with two units of Pol III. DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur Kornberg) and Malcolm Gefter in 1970. The complex has high processivity (i.e. the number of nucleotides added per binding ...

  7. Replisome - Wikipedia

    en.wikipedia.org/wiki/Replisome

    RFC deposits the sliding clamp and attracts DNA polymerases such as alpha (α), delta (δ), epsilon (ε). For both bacteria and eukaryotes, the next stage is generally referred to as 'elongation', and it is during this phase that the majority of DNA synthesis occurs.